It's not that I'm only trying to justify a new rifle and I understand that really is no such thing as over-dead...but there is such a thing as over kill. Confuscious say no need to kill mosquito with cannonball

I do not have a medium bore rifle so I'm leaning towards the 25-06. Brass is a little more readily available and ammo isn't Weatherby prices

I don't want to hit the pronghorn with my 300 WSM and lose 1/2 the meat to jello. Over exaggeration I know

My reloading manuals pretty much agree that with proper bullet selection I could hunt all 3 species I listed above with any of the calibers listed above (none of which I presently own) so I was looking for a little feedback with the understanding that everyone has their own favorites.
In the end, there is a 99% chance I will buy a new rifle for the reasons listed previously. Now the hard part will probably be getting a composite stock instead of a really nice wood stock which I prefer. I've read a lot about stalking pronghorns & sometimes crawling around to get a good shot.