I shoot a 300 Wby. in a McMillan stocked Mod 70. I also shoot 22-250, 243 & 17 Rem @ varmints and these cartridges have almost identical trajectory. The 300 Wby is one of the finest long range cartridges out there and it also does not want for terminal ballistics.
My buddy has the same rifle and needed to put a muzzle break on his. I really don't mind the recoil from it. It has a lot of velocity, but is not as severe as the 12 ga Ithaca Deerslayers w/3" slugs or a Marlin 1895 w/max loads.