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I have the KelTec PMR30 and it's a really fun little gun to shoot. They have very little recoil, a good trigger, are easy to rack the slide, and it shoots well. Even with a full mag they aren't particularly heavy but I'm not sure how concealable they would be and the FN 5.7 is even a bit larger yet. They make great back pack guns but I'm not sure how well you'd like one as a CCW.My wife carries a Ruger LCR 38spl and its pretty manageable for her to shoot and she's no particular fan of recoil.A couple other guns your wife may enjoy shooting, is the M&P Shield 380 EZ or the M&P Shield 9mm.
I just recently bought my wife a Walther PK380. Its super soft shooting and the action is manageable with a weaker grip (arthritis). My wife really liked it.
Check out the 22 TCM also.https://www.gunbroker.com/item/786314452
Are you or her set on a .22? I bought my wife a bodyguard .380 and she loves it. I bought a ruger lcp .380 to carry part time and I bought two (2) 10 round mags and i like it. Just a thought.