Determine the primary use for any gun, then determine what gun best suits that task.
If all you're looking for is a gun to carry as self defense, then yes, a snubby 38spl, (Taurus85, Ruger LCR), 357mag, (SP101), Glock in various semi-auto cartridges. (I hate Glocks so I'll just say HK, Ruger, Glock, or other plastic/hybrid semi-auto) will do fine.
If you're looking to hunt with pistol, you'll need a bit more fire power, like 44mag (Ruger Redhawk or Super Blackhawk), and above with at least 6" barrel. If you're looking to carry concealed, while just hiking in the woods, then a revolver with say... 4" barrel in at least 357mag would be a fine choice for cats, bears at close range protection and meth heads. (Ruger GP100)
If you've got more money to spend, Kimber, Colt, DanWesson, 1911 in 45acp would be fine.
-Steve