I will go out on the limb and say that .204 ruger is the best coyote round if you plan on selling the skins to the fur market. I reload 35grain Bergers pushing just under 4000fps. In the past I've shot .223, .222, 22-250, .17Rem, and .243. My shots have been anywhere from 10 yards to 350 yards. 99.9% of the time you have a .20 caliber entry hole and no exit and their insides are jello. Even on a poor shot placement I've recovered ALL my coyotes, but most of the time they just tip over. My 2 cents.