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I'm no expert but i have a .54 cal muzzy and use 95 gr. of pyrodex powder but have used the pellets too. I went to powder as I was trying out so many different combos, so i bought a jar of it. I like the 295 or 300 grain sabotted bullets by barnes. It took me a while to find the right sabots as some did not fit in my muzzle correctly. I think 60gr with a 430 gr bullet is not enough. Go shoot and see. Good luck. Also get a peep site if you dont have one. they work really good.
The convenience of Pyrodex Pellets is also available for the 54 caliber in-line rifles. Coupled with a 54 caliber sabot and a 50 caliber bullet or with Power Belt bullets creates a powerful combination for really big game. Pyrodex 54 caliber pellets are not recommended for use with conical bullets with or without wads. Packed 100 pellets to the box.