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It's all about getting your legs and back in shape.
I start with nominal weight (25-30 lbs) and get my cardio up to snuff. Then, when I'm starting to feel pretty damn good about myself, I start adding weight, more ups and downs on my hiking course (the downs are as important as the ups.. ask my knees how I know this)
The more time you spend with a weighted pack the better. Just doing squats and core will not help the pulling, twisting and pressure the pack straps do on your shoulders and waist. Get your body use to the discomfort. Oh, and 600 mg of Advil.
Go down to the Home Depot parking lot and buy yourself a few Mexicans! Other than that hike a lot with jugs of water on your back. And get the best dang pack and best footwear you can afford!If you are under the age of 21...buy a belt and pull your dang pants up
Hit the weights cleans, squats, dead lift. Calves, thighs, abs, and back mixed with some good hill runs and you will be ready for those tough packs.
I smoke cigarettes though, so i should probably work on quitting that if i want to actually reach a decent peak in cardio performance.
My old mizunos have about 1750 miles on them.