Your Favorite Caliber For Deer

[SuperDave]

Ruger M-77 .257 roberts, shooting 87 gr. spitzers!  Never have had one run off!

[Old Wanderer]

Pre 64, 264 Win Mag....120 GR 

[Birdguy]

Whatever is an my hand (or arms reach) during the season  from .243 to 7mm. Just depends when deer, season, and tag collide. As a Washington sportsman I take what I can when I can.

[jeepasaurusrex]

.270 with 130gr Ballistic silver tips for deer, 150gr Barnes Triple shocks for Elk.

[Wacenturion]

Early 1960's Sako Mannlicher .308 with a 2x8 Burris Signature.   

[finnman]

I love that scope Wacenturion! I have one on the .338 win mag.
My deer rifle of choice, Weatherby Ultra lightweight in .280 Rem. topped with a 3.5x10 Burris 50mm scope, shooting 140 gr. Federal loads, total weight a shade over 7 lbs.
My wife shots a Weatherby stainless lightweight carbine, they quit making this rifle a few years ago, hers is in 7MM-08 topped with a Leupold Vari-x III 2x8, shots 140 gr. Nosler Ballistic Tips real well.

[Timberstalker]

Though I havent Rifle hunted for a few years it is definelty My 25-06  I sure love that Gun.

[Wea300mag]

.270 and 7mm, but most of the time I'm carrying the 300Wea  .

[PacificNWhunter]

.300 Win Mag 150 grn

[deerslyr]

Knight MK85 shooting a 348 grain power belt with 110gr of 777 
But if I have to use a rifle ill go with my 270 topped by an alaskan guide 3.5-10x44 shooting 130 light mags.

[Curly]

I use a Steyr Prohunter in .300 Win Mag and reloaded 168gr Barnes TSX.  Topped w/ a Leupold Vari X III 3.5-10 x 50.

Someday I plan on getting a lighter weight rifle for deer..........leaning toward a Browning X-Bolt in 7mm-08.

[CP]

I don’t have a favorite; I like using different weapons.  I’ve had good luck with these to name a few:

.250 Savage
.243
.30-06
12 gauge
20 gauge
.45 colt
.44 mag
.357 mag
.270
.54 cal

They all work, the only thing that I tried and didn’t like was a bow.  I’m sure that they work too but just not my thing.

[klickman]

ANohter vote for archery.  The one deer I did shoot with a rifle it was a 243.  That is a fun little gun. 

KLICKMAN

[WDFW-SUX]

7mm Rem Mag 140 grain TSX 67grains of RL 22 =

[Pathfinder101]

When I was a kid, my grandpa had a subscription to Outdoor Life from about 1950 until he died in 1991.  He kept them all in his basement in stacks and I used to read them whenever I was over there.  (Some of you probably already know where this is going...). 
As a result, I guess you could say that Jack O'Connor reached back from beyond the grave and sold me my first .270 as soon as I was old enough to earn the money to buy my own rifle (I think I was 15).  That is still the only caliber I use for deer.  I moved back to Washington in 2001, and upgraded my old .270 (a Husquarvana) to a Remington 700 in the same caliber.  I shoot 130 grain Federal Premiums, or some hot 140 grain handloads that a buddy put together for me.  In 8 years I have shot 7 deer with it, 4 mulies and 3 whitetails.  5 of the 7 died where they were standing, the other two ran less than 100 yards.  I try to break both shoulders if I can.  For me out here in Walla Walla wheat country a powerful scope and a bipod are essential.   
My 9 year old carries a .243 (got his first buck with it this fall), but actually shoots my rifle better than he does his (just too heavy for him to carry very far).  Our standing deal is that if the animal is past 100 yards, he will use my gun.
A kid that works with me just got into hunting a couple of years ago, borrowed my rifle for a weekend, and went out last year and bought my same setup, but in 30-06.  He was going to buy a .270 but got a deal on the 30-06.  When I was younger I would have gone to blows over the .270/30-06 debate (Kettle Falls High School had two distinct camps on this subject-I think that's the closest we ever got to street gangs-and you were either on one side or the other...).  I have come to believe though that neither one has a clear advantage over the other. 
Still love that .270 though.  Planning to take my son to the Jack O'Connor Museum in Lewiston this winter sometime...